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194

抑制剂 & 化合物

51

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22336	Galloflavin	Dehydrogenase	Metabolism
	Galloflavin 是乳酸脱氢酶抑制剂。用 Pyruvate 法得到的 Ki 为 5.46 µM (LDH-A) 以及15.06 µM (LDH-B)。它能够阻断 ATP 的生成和糖酵解，从而抑制癌细胞的增殖。
T2325	Neratinib HKI-272,来那替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib (HKI-272) 是一种口服的、不可逆的酪氨酸激酶抑制剂，对 HER2 和 EGFR 的 IC50值分别为 59 和 92 nM。
T4337	PCI 29732 PCI29732,PCI-29732	Others; BCRP; BTK	Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors
	PCI 29732 是一种有效的可逆BTK 抑制剂，对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。
T13044	Mevociclib SY-1365	CDK	Cell Cycle/Checkpoint
	Mevociclib (SY-1365) 是一种高效选择性 CDK7抑制剂，Ki 值为 17.4 nM。它具有抗血液肿瘤和侵袭性实体肿瘤作用，有抗增殖和凋亡活性。
T27730	KGP94 KGP-94,KGP 94	Cysteine Protease	Proteases/Proteasome
	KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。
T6797	Telaglenastat CB 839,CB839,CB-839	transporter; Glutaminase; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Telaglenastat (CB 839) 是一种选择性可逆的，有口服活性的谷氨酰胺酶 1 (GLS1) 抑制剂，抑制 GLS1剪接变异体 KGA 和 GAC，比 GLS2 具有更高的选择性。它可诱导细胞自噬，具有抗肿瘤活性。它对小鼠类肾和脑中的内源性谷氨酰胺酶的 IC50值分别为 23 nM 和 28 nM。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T6496	Vactosertib TEW-7197,EW-7197	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	Vactosertib (EW-7197) 是有效的、具有 ATP 竞争性的、具有口服活性的激活素受体样激酶 5 (ALK5) 抑制剂(IC50:12.9 nM)。它还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50为 17.3 nM)，表现出强大的抗转移活性和抗癌作用。
T6303L	CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis; Akt; PKA; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 hydrochloride (CCT128930 hydrochloride) 是一种选择性 AKT 抑制剂，具有抗肿瘤活性。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T6303	CCT128930	Akt; PKA; S6 Kinase; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 是一种 ATP 竞争性，选择性 AKT 抑制剂。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性，具有抗肿瘤活性。
T12906	SI-2 hydrochloride EPH 116 hydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	SI-2 hydrochloride (EPH 116 hydrochloride) 是 SRC-3 的抑制剂，诱导乳腺癌细胞死亡的 IC50 值为 3-20 nM。SI-2 hydrochloride 具有良好的药代动力学特征和改善的毒性，以及可接受的口服可用性。
T37518	Diphenyl disulfide Phenyl disulfide	Apoptosis; BCL; Endogenous Metabolite	Apoptosis; Metabolism
	Diphenyl disulfide (Phenyl disulfide) 在乳腺癌细胞系中显示出抗癌活性。Diphenyl disulfide 通过Bax 蛋白水解活化和伴随的自噬来诱导并增强乳腺癌细胞的凋亡。Diphenyl disulfide 以剂量依赖性方式抑制细胞增殖和活力，并减少集落形成。Diphenyl disulfide 可用来治疗乳腺癌。
T9468	FR054	Others	Others
	FR054 是一种己糖胺生物合成途径酶 PGM3 的抑制剂，具有明显的抗乳腺癌活性。它在不同的乳腺癌细胞中诱导细胞增殖和存活显著降低。
T27093	CT-1 CT 1	p53	Apoptosis
	CT-1 是一种 DNA 小沟配体，可导致 p53 依赖性乳腺癌细胞凋亡。
T34262	RAPTA-C	Apoptosis	Apoptosis
	RAPTA-C 可通过线粒体和 p53-JNK 途径诱导 EAC 细胞周期停滞和凋亡，可用于研究乳腺癌和卵巢癌。
T7311	Oxyphenisatin acetate	Autophagy	Autophagy
	Oxyphenisatin acetate 是oxyphenisatin 的前体药物，可抑制乳腺癌细胞系 MCF7、T47D、HS578T 和 MDA-MB-468 的生长。
T14685	BMS-986158	Epigenetic Reader Domain	Chromatin/Epigenetic
	BMS-986158 是一种BET 抑制剂，在 MDA-MB231 三阴性乳腺癌细胞和 NCI-H211 小细胞肺癌细胞中，对 BET 的IC50分别为 5 和 6.6 nM。
T72528	NSC243928 mesylate	HuR	Chromatin/Epigenetic
	NSC243928 mesylate 可与人类淋巴细胞抗原 6 (LY6) 结合，是细胞生长抑制剂，具有抗癌活性，以 LY6K 依赖性方式诱导三阴性乳腺癌细胞的细胞死亡。
T4400	DIM-C-pPhOH CDIM8	Apoptosis; Others	Apoptosis; Others
	DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂，可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。
T27133	DCLX069 DCLX 069,DCLX-069	Histone Methyltransferase	Chromatin/Epigenetic
	DCLX069 是一种选择性蛋白精氨酸甲基转移酶 1 抑制剂，IC50值为 17.9 µM，对 PRMT4 和 PRMT6 的活性较低。它可有效阻断乳腺癌、肝癌和急性髓性白血病细胞系中的细胞增殖。
T9583	HJ-PI01 N-Acetylphenoxazine,10-acetylphenoxazine	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	HJ-PI01 (HJ-PI01) 是一种 Pim-2 抑制剂。它在三阴性人乳腺癌中诱导细胞凋亡和自噬性细胞死亡。
T28754	Sepin-1 Sepin 1,Sepin1,2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide	Others	Others
	Sepin-1 是一种分离酶的非竞争性抑制剂，IC50 为 14.8 µM。 Sepin-1可以通过抑制细胞增殖和诱导细胞凋亡来抑制小鼠和人类癌细胞系乳腺癌异种移植瘤的生长。
T28543	RK-9123016 RK9123016,RK 9123016	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A（eIF5A）（SIRT2的生理底物）的乙酰化水平，降低人乳腺癌细胞的细胞活力，同时降低c-Myc 表达。
T26897	BRD2492	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD2492 是一种具有选择性和有效的 HDAC1 和 HDAC2 双重抑制剂，具有潜在的抗癌、抗肿瘤和抗增殖活性，抑制 HDAC1/2 、HDAC3 和 HDAC6。BRD2492 对乳腺癌细胞系的生长有抑制作用，诱导细胞凋亡。
T10735	CDK4/6/1 Inhibitor Crozbaciclib	CDK	Cell Cycle/Checkpoint
	CDK4/6/1 Inhibitor (Crozbaciclib) 是一种 CDK4/6 抑制剂 (IC50s: 3 and 1 nM). CDK4/6抑制剂是一类用于治疗一些类型的激素受体阳性、her2阴性乳腺癌的化合物，可阻断了乳腺癌细胞分裂和繁殖的过程。
T60757	SB-216	Microtubule Associated	Cytoskeletal Signaling
	SB-216 可用于研究癌症，是微管蛋白聚合的有效抑制剂。SB-216 在一组人类癌细胞系中表现出强大的抗增殖能力，包括黑色素瘤、乳腺癌和肺癌。
T62491	STAT3-IN-13	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-13 是一种有效的 STAT3 抑制剂。STAT3-IN-13 具有抗增殖和抗癌活性，通过与 STAT3 SH2 结构域结合发挥作用。STAT3-IN-13 抑制 STAT3 Y705 的磷酸化，诱导细胞凋亡，抑制肿瘤细胞的生长和转移。STAT3-IN-13 可用于研究乳腺癌和肝癌。
T67846	AKR1C3-IN-9	NADPH	Metabolism
	AKR1C3-IN-9 是选择性的醛酮还原酶 1C3 (AKR1C3) 抑制剂 (IC50= 8.92 nM)。AKR1C3-IN-9 显著逆转在耐药乳腺癌细胞系对 Doxorubicin (DOX) 耐药性。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T61899	VEGFR2-IN-1	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR2-IN-1 是一种具有选择性和高效性的 VEGFR2 抑制剂，具有抗肿瘤活性，可抑制细胞的增殖和迁移，可用于研究乳腺癌。
T72968	ZINC00640089	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ZINC00640089 是一种选择性的脂质运载蛋白-2 (LCN2) 抑制剂。ZINC00640089 对细胞增殖、细胞活力有抑制作用，可减少 SUM149 细胞的 AKT 磷酸化水平。ZINC00640089 可用于研究炎症性乳腺癌 (IBC) 。
T16436	PBOX 6 PBOX-6	Apoptosis	Apoptosis
	PBOX 6 是一种 pyrrolo-1,5-benzoxazepine (PBOX) 化合物，具有抗癌抗肿瘤活性，可在体外抑制乳腺癌细胞的生长，在白血病细胞中通过 c-Jun NH2 末端激酶依赖性磷酸化、 Bcl-2 和 Bcl-XL 的失活发生选择性诱导细胞凋亡。
T5350	JG-98 JG98,JG 98	Apoptosis; HSP	Apoptosis; Cytoskeletal Signaling; Metabolism
	JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞，具有抗癌活性。
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T22646	CFM 4 CFM-4,CFM4	Apoptosis; APC	Apoptosis; Cell Cycle/Checkpoint
	CFM 4 是一种有效的小分子 CARP-1/APC-2 拮抗剂，阻止 CARP-1 与 APC-2 结合，促使 G2M 细胞周期阻滞，引起细胞凋亡，其 IC50 范围为 10-15 μM。CFM 4 对耐药人类乳腺癌细胞的生长有抑制作用。
T36970	STD1T	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	STD1T 是一种具有选择性和有效性的脱泛素酶 USP2a 抑制剂，具有潜在的抗癌活性，可降低 HCT116 结肠和 MCF-7 乳腺癌细胞中的细胞周期蛋白 D1 蛋白水平。
T1916	Apitolisib RG 7422,GNE 390,GDC-0980	Apoptosis; PI3K; mTOR	Apoptosis; PI3K/Akt/mTOR signaling
	Apitolisib (RG 7422) 是一种口服有效的 PI3K 和 mTOR(TORC1/2) 激酶抑制剂，抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ的活性，IC50值为 5 nM/27 nM/7 nM/14 nM，抑制 mTOR，Ki 为 17 nM。它用于乳腺癌、前列腺癌、肾细胞癌和子宫内膜癌等实体癌的试验研究。
T77701	FL118 FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin	Apoptosis
	FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。
T60039	KSQ-4279 USP1-IN-1	PARP; DUB	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination
	KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性，可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T9657	FiVe1	Others	Others
	FiVe1是一种波形蛋白结合小分子，在中期促进波形蛋白解体和磷酸化，导致有丝分裂灾难，多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞（FOXC2-HMLER 细胞IC50=234nM）和不同组织学亚型的软组织肉瘤的生长。
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T10895	CSN5i-3	Apoptosis; Others	Apoptosis; Others
	CSN5i-3 是一种新型有效口服且具有选择性的 CSN5/Jab1 抑制剂，抑制 CSN 催化的 Cul1 deneddylation IC50 值为 5.8 nM。CSN5i-3具有抗癌活性，抑制细胞增殖并诱导人乳腺癌细胞凋亡。
T77122	Praluzatamab	Others	Others
	Praluzatamab 是一种靶向活化白细胞粘附分子 (ALCAM/CD116) 的单克隆抗体。Praluzatamab 是 Praluzatamab ravtansine 的裸抗，可用于合成抗体活性分子偶联物（Praluzatamab ravtansine)。Praluzatamab 可用于研究研究乳腺癌。
T77059	Leronlimab PRO 140	CCR	Immunology/Inflammation; Microbiology/Virology
	Leronlimab (PRO 140) 是一种人源化 IgG4 抗 CCR5 单克隆抗体。leronlimumab 具有抗 HIV 病毒活性和抗肿瘤活性，抑制 CCR 介导的 HIV-1 病毒和小鼠肿瘤模型中癌细胞转移。Leronlimab 可用于研究 HIV 非酒精性脂肪性肝炎 (NASH) 和乳腺癌。
T83627	Pim-1 kinase inhibitor 8	Pim; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling
	Pim-1 kinase inhibitor 8 是一种高效的 Pim-1 kinase 抑制剂，具有抗癌活性，可有效抑制细胞迁移。Pim-1 kinase inhibitor 8 对 MCF-7 和 HepG2 细胞有细胞毒性，是研究乳腺癌的候选化合物。
T15713	Larotaxel XRP9881	P-gp	Membrane transporter/Ion channel; Neuroscience
	Larotaxel (XRP9881) 是一种紫杉烷类似物，具有抗癌活性，通过促进微管蛋白装配和稳定微管发挥其细胞毒性作用，并通过细胞凋亡诱导细胞死亡。Larotaxel (XRP9881) 是一种可穿过血脑屏障的化合物，对 Docetaxel 的亲和力比 P-糖蛋白 1 高，可用于研究乳腺癌和膀胱癌。
T28773	SI-2 SI2,EPH 116,EPH116,EPH-116	Others	Others
	SI-2是类固醇受体辅激活因子-3（SRC-3或 AIB1）的抑制剂（SMI）。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度，并选择性诱导低纳摩尔范围（3-20 nM）内的乳腺癌症细胞死亡，但不影响正常细胞存活率。

化合物

Cat.No: T22336

Target: Dehydrogenase

Cat.No: T2325

Synonym: HKI-272,来那替尼

Target: EGFR, HER

Cat.No: T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

Cat.No: T13044

Synonym: SY-1365

Target: CDK

Cat.No: T27730

Synonym: KGP-94,KGP 94

Target: Cysteine Protease

Cat.No: T6797

Synonym: CB 839,CB839,CB-839

Target: transporter, Glutaminase, Autophagy

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Cat.No: T6496

Synonym: TEW-7197,EW-7197

Target: ALK, TGF-beta/Smad

CCT128930 hydrochloride

Cat.No: T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Cat.No: T6303

Target: Akt, PKA, S6 Kinase, Autophagy

SI-2 hydrochloride

Cat.No: T12906

Synonym: EPH 116 hydrochloride

Target: Src

Diphenyl disulfide

Cat.No: T37518

Synonym: Phenyl disulfide

Target: Apoptosis, BCL, Endogenous Metabolite

Cat.No: T9468

Target: Others

Cat.No: T27093

Synonym: CT 1

Target: p53

Cat.No: T34262

Target: Apoptosis

Oxyphenisatin acetate

Cat.No: T7311

Target: Autophagy

Cat.No: T14685

Target: Epigenetic Reader Domain

NSC243928 mesylate

Cat.No: T72528

Target: HuR

Cat.No: T4400

Synonym: CDIM8

Target: Apoptosis, Others

Cat.No: T27133

Synonym: DCLX 069,DCLX-069

Target: Histone Methyltransferase

Cat.No: T9583

Synonym: N-Acetylphenoxazine,10-acetylphenoxazine

Target: Pim

Cat.No: T28754

Synonym: Sepin 1,Sepin1,2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide

Target: Others

Cat.No: T28543

Synonym: RK9123016,RK 9123016

Target: Sirtuin

Cat.No: T26897

Target: HDAC

CDK4/6/1 Inhibitor

Cat.No: T10735

Synonym: Crozbaciclib

Target: CDK

Cat.No: T60757

Target: Microtubule Associated

Cat.No: T62491

Target: STAT

Cat.No: T67846

Target: NADPH

Cat.No: T9089

Synonym: UUN44923

Target: Others

Cat.No: T61899

Target: VEGFR

Cat.No: T72968

Target: Akt

Cat.No: T16436

Synonym: PBOX-6

Target: Apoptosis

Cat.No: T5350

Synonym: JG98,JG 98

Target: Apoptosis, HSP

Tubulin polymerization-IN-47

Cat.No: T77651

Target: Microtubule Associated

Cat.No: T22646

Synonym: CFM-4,CFM4

Target: Apoptosis, APC

Cat.No: T36970

Target: DUB

Cat.No: T1916

Synonym: RG 7422,GNE 390,GDC-0980

Target: Apoptosis, PI3K, mTOR

Cat.No: T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Survivin

Cat.No: T60039

Synonym: USP1-IN-1

Target: PARP, DUB

Cat.No: T10904

Target: Wnt/beta-catenin

Cat.No: T9657

Target: Others

Cat.No: T17206

Target: Others, Glutaminase

Cat.No: T10895

Target: Apoptosis, Others

Cat.No: T77122

Target: Others

Cat.No: T77059

Synonym: PRO 140

Target: CCR

Pim-1 kinase inhibitor 8

Cat.No: T83627

Target: Pim, PKC

Cat.No: T15713

Synonym: XRP9881

Target: P-gp

Cat.No: T28773

Synonym: SI2,EPH 116,EPH116,EPH-116

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2105	Proscillaridin A	Topoisomerase	DNA Damage/DNA Repair
	Proscillaridin A 是从Drimia robusta 中提取的一种天然产物。是强力的拓扑异构酶 I 和 II 的抑制剂，IC50值分别为 30 nM 和 100 nM。
T4964	steviolbioside CCRIS-6025,菊双糖甙,甜菊双糖苷	Others	Others
	Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用，对乳腺癌具有潜在的研究价值。
T7849	Norspermine	Others	Others
	Norspermine 是一种多胺类似物，用于治疗非小细胞肺癌和乳腺癌。
TN1346	Oxypalmatine 8-Oxypalmatine	Apoptosis	Apoptosis
	Oxypalmatine (8-Oxypalmatine) 是在 Phellodendron amurense 中分离出来的小檗碱型生物碱，通过抑制 PI3K/AKT 信号传导及其对乳腺癌类器官的功效来调节乳腺癌细胞的增殖和凋亡。
T5744	7-Prenyloxycoumarin 7-(异戊烯基氧基)香豆素,Nsc267697,7-O-Prenylumbelliferone,7-异戊烯氧基香豆素	Antifungal	Microbiology/Virology
	7-Prenyloxycoumarin (Nsc267697) 是一种 Heracleum dissectum 的天然产物，对乳腺癌具有预防和治疗作用。
T6S2038	Ziyuglycoside II	Apoptosis; Antioxidant; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Ziyuglycoside II 是从地榆中提取的一种三萜皂苷，可诱导活性氧产生和凋亡，具有抗炎和抗癌作用。
T2S0265	Robinin NSC 9222,刺槐素	TLR	Immunology/Inflammation
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T5S0506	Rotundic acid Rutundic acid,铁冬青酸	Apoptosis; Others; p38 MAPK; Akt; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling
	Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物，具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
TN3628	Chamaejasmenin B	Others	Others
	Chamaejasmenin B 是一种从 Stellera chamaejasme L 中分离得到的化合物。Chamaejasmenin B 具有抗癌和抗肿瘤活性，可抑制癌细胞迁移和侵袭，抑制肿瘤转移。Chamaejasmenin B 可用于研究如乳腺癌类的癌症。
TN1222	26-Deoxyactein 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭	NOS; CDK; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation
	23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分，能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR，CYP1A1 和 ERK 的水平升高具有抑制作用。
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3923	Calycosin Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮	Apoptosis; Tyrosinase	Apoptosis; Proteases/Proteasome
	Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
TN5371	8-Hydroxy-ar-turmerone
	8-Hydroxy-ar-turmerone may exhibit antitumor activity against breast cancer cells via cell death and cell cycle arrest.
TN3362	Aglinin A	Others	Others
	Aglinin A displays moderate cytotoxicity against all the three cancer cell lines((NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines).
TN3560	Cabralealactone	Antifection	Microbiology/Virology
	Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line.
T81689	Neohelmanthicin A
	Neohelmanthicin A（compound 3A）是具抗肿瘤活性的苯丙素类化合物。该化合物对EL4白血病细胞系、S180乳腺癌细胞系和MCF7乳腺癌细胞系表现出显著的抑制作用，其IC50s分别为0.13 μM, 7 μM和23 μM。
TN4261	Isoaltenuene	Antifection	Microbiology/Virology
	Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line
TN2371	Isoliquiritin 新异甘草苷,Neoisoliquiritin	Others	Others
	Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway
TN4963	Scillascillin	Others	Others
	Scillascillin has anticancer activity, it is significantly active against human cancer cell lines MCF-7 (breast cancer) and DU-145 (prostate cancer) with inhibitory concentration (IC)50 values 9.59 and 11.32 ug/ml respectively.
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN1392	Anhydrosecoisolariciresinol	Others	Others
	Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM.
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a
TN2752	2-Deacetoxytaxinine J	Others	Others
	2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
TN2493	1,4,5,6-Tetrahydroxy-7-prenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2.
TN5190	Tryprostatin A	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase.
T73067	Isodispar B
	Isodispar B，一种抗癌剂，能够抑制鼻咽癌和乳腺癌细胞的增殖，并诱导(apoptosis)。它对多种癌细胞系展示出了细胞毒性作用。
TN3559	Cabraleahydroxylactone	HSV	Microbiology/Virology
	Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).
TN3557	Cabraleadiol	ATPase; Antifection	Membrane transporter/Ion channel; Microbiology/Virology
	Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi
TN1985	Neoprzewaquinone A	ROCK; Pim; STAT	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells
	Neoprzewaquinone A (NEO) 是 S. miltiorrhiza 的活性成分，通过靶向 PIM1 阻断 ROCK2/STAT3 通路来抑制乳腺癌细胞迁移并促进平滑肌松弛。
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...
TN2767	2'-Hydroxygenistein 鲁冰花	Antifection	Microbiology/Virology
	2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. 2'-Hydroxygenistein of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
T81769	Mollicellin I
	Mollicellin I（compound 1）为一种Depsidone类化合物。其对Bre04人乳腺癌细胞系、Lu04人肺癌细胞系以及N04人神经瘤细胞系的生长抑制活性低，GI50s均超过10 μg/mL。
TN3084	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone	Estrogen Receptor/ERR; Others	Endocrinology/Hormones; Others
	5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 具有抗癌活性，体外对 ER 阳性乳腺癌MCF-7细胞表现出较强的抗增殖作用，对MCF-7细胞的IC50值为4.41 uM。5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 能显著下调雌激素受体-α (ER-α)的表达浓度，并能抑制人乳腺癌细胞系BCAP-37异种移植模型体内的肿瘤生长。
TN3401	Altenuene	Antifection	Microbiology/Virology
	Altenuene 是一种霉菌毒素，经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。
TN4552	Methyl p-hydroxyphenyllactate	Others	Others
	Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS)
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
TN3924	Eichlerialactone	Others	Others
	Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25-50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gr
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
T35758	Butyrolactone V
	Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also...
T81770	Mollicellin H
	Mollicellin H, 次级代谢物源于真菌C. brasiliense，显示出免疫调节、细胞毒性和抗肿瘤等多种生物活性。它对三种人类癌细胞系——乳腺癌 (Bre04)、肺癌 (Lu04) 和神经瘤 (N04) 的生长抑制半数有效浓度 (GI50s) 分别为5.1 μg/mL、6.5 μg/mL 和2.5 μg/mL。
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
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天然产物

Proscillaridin A

Cat.No: TN2105

Target: Topoisomerase

Cat.No: T4964

Synonym: CCRIS-6025,菊双糖甙,甜菊双糖苷

Target: Others

Cat.No: T7849

Target: Others

Cat.No: TN1346

Synonym: 8-Oxypalmatine

Target: Apoptosis

7-Prenyloxycoumarin

Cat.No: T5744

Synonym: 7-(异戊烯基氧基)香豆素,Nsc267697,7-O-Prenylumbelliferone,7-异戊烯氧基香豆素

Target: Antifungal

Ziyuglycoside II

Cat.No: T6S2038

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Cat.No: T2S0265

Synonym: NSC 9222,刺槐素

Target: TLR

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T5S0506

Synonym: Rutundic acid,铁冬青酸

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Chamaejasmenin B

Cat.No: TN3628

Target: Others

Cat.No: TN1222

Synonym: 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭

Target: NOS, CDK, NO Synthase

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Cat.No: T7032

Target: Others, P450

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3923

Synonym: Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮

Target: Apoptosis, Tyrosinase

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

8-Hydroxy-ar-turmerone

Cat.No: TN5371

Cat.No: TN3362

Target: Others

Cabralealactone

Cat.No: TN3560

Target: Antifection

Neohelmanthicin A

Cat.No: T81689

Cat.No: TN4261

Target: Antifection

Cat.No: TN2371

Synonym: 新异甘草苷,Neoisoliquiritin

Target: Others

Cat.No: TN4963

Target: Others

Cat.No: TN4355

Target: Others

Anhydrosecoisolariciresinol

Cat.No: TN1392

Target: Others

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone

Cat.No: TN2492

Target: Others

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

1,3,9-Trimethyluric acid

Cat.No: TN6062

2-Deacetoxytaxinine J

Cat.No: TN2752

Target: Others

1,4,5,6-Tetrahydroxy-7-prenylxanthone

Cat.No: TN2493

Target: Others

Cat.No: TN5190

Target: Topoisomerase, Antifection

Cat.No: T73067

Cabraleahydroxylactone

Cat.No: TN3559

Target: HSV

Cat.No: TN3557

Target: ATPase, Antifection

Neoprzewaquinone A

Cat.No: TN1985

Target: ROCK, Pim, STAT

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

2'-Hydroxygenistein

Cat.No: TN2767

Synonym: 鲁冰花

Target: Antifection

Cat.No: T81769

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

Cat.No: TN3084

Target: Estrogen Receptor/ERR, Others

Cat.No: TN3401

Target: Antifection

Methyl p-hydroxyphenyllactate

Cat.No: TN4552

Target: Others

Cat.No: T36815

Eichlerialactone

Cat.No: TN3924

Target: Others

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Sartorypyrone B

Cat.No: T81201

Butyrolactone V

Cat.No: T35758

Cat.No: T81770

Cat.No: T37452

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